The study showed that mice who ate very low-calorie foods lived longer, regardless of how much glucose or fat they had.
This study could provide new insights into the benefits of caloric restriction in human longevity.
A study showed that mice who lived longer were more likely than others to maintain their weight by eating less.
To determine the impact of different dietary patterns on lifespan, a team of researchers conducted a study that involved five female groups: Two with restricted caloric intake (60 and 80 per cent below baseline) and one with unlimited food access. The other two were subjected to intermittent fasting.
According to the study, mice fed a diet without restrictions lived an average of 28 months. Mice that had an intermittent fasting regimen lived an average of 25 months. The mice that consumed 80% of their baseline calories lived for 30 months. However, those who only consumed 60 per cent of calories survived for an additional 34 months.
Although they identified the genetically encoded resistance as an important factor in longevity, researchers found that diets had less impact than genetic factors.
The study leader, Gary Churchill, said, “Our research confirms the importance of resilience.” The most resilient animals maintain weight under stressful conditions and calorie restrictions and live longer. It is possible that the best way to balance long-term health with longevity would be to restrict calories at a moderate rate.
If you’re looking to live long, you have things that you can do within your lifetime. For example, you could control your diet. Our data shows that while caloric restrictions generally benefit longevity, losing weight is detrimental to lifespan.
When we examine human trials for longevity drugs and find that the people taking them have lost weight and improved metabolic profiles, it may not indicate their life expectancy.
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